126 research outputs found
Strong 3D correlations in vortex system of Bi2212:Pb
The experimental study of magnetic flux penetration under crossed magnetic
fields in Bi2212:Pb single crystal performed by magnetooptic technique (MO)
reveals remarkable field penetration pattern alteration (flux configuration
change) and superconducting current anisotropy enhancement by the in-plane
field. The anisotropy increases with the temperature rise up to . At an abrupt change in the flux behavior is found; the
correlation between the in-plane magnetic field and the out-of-plane magnetic
flux penetration disappears. No correlation is observed for . The
transition temperature does not depend on the magnetic field strength.
The observed flux penetration anisotropy is considered as an evidence of a
strong 3D - correlation between pancake vortices in different CuO planes at . This enables understanding of a remarkable pinning observed in
Bi2212:Pb at low temperatures.Comment: 8 pages, 9 figure
Synthesis and Antibacterial Activity of Hydrazones of Isonicotinic and Salicylic Acids Based on Acetyl Derivatives of Coumarin and Benzo[g][1,3,5]Oxadiazocine
In recent decades, the efforts of many researchers in the sphere of organic chemistry, physics and pharmacol-ogy have been focused on the search for new agents with pronounced antibacterial and especially antifungal activity. This is due to the widespread increase in the resistance of many bacterial strains and fungi to antibi-otics and antifungal drugs available in medical practice. In this regard, the number of works related to the synthesis of new potential antibiotics from the most diverse class of organic derivatives, which either include known pharmacophore groups or represent a new structural class of compounds with unknown and unex-plored activity, is increasing in the scientific literature. In this work, new previously undescribed hydrazones derivatives were obtained on the basis of physiologically active isonicotinic and salicylic acid hydroxides and laboratory-available acetyl-substituted heterocycles, namely 3-acetyl-2H-chromen-2-one 3,2-acetyl-3H-benzo[f]chromen-3-one 4 and 2,6-methanobenzo[g][1,3,5]oxadiazocine 5. The obtained hydrazones structure is explicitly proved by IR and 1H, 13C NMR spectroscopy data. The synthesized six new hydrazones under-went biological screening for antibacterial and antifungal activity on strains of microorganisms, namely gram-positive bacterium Staphylococcus aureus 209P, gram-negative bacterium Pectobacterium carotovorum VKM-B1247, and yeast-like fungus Candida albicans ATCC 10231. Screening revealed three compounds with antimicrobial activity and one promising compound — (E)-2-hydroxy-N’-(1-(2-oxochroman-3-yl)ethylidene)benzohydrazide 9, which also exhibits antifungal activity along with antimicrobial activity
Исходы новой коронавирусной инфекции COVID-19 у 68 пациентов с воспалительными заболеваниями кишечника
Background. COVID-19 is an infectious respiratory syndrome with a wide range of manifestations and outcomes. Patients with inflammatory bowel disease (IBD) generally have a higher risk of infection, especially if they receive immunosuppressive therapy.
Aim to describe the manifestations of COVID-19 in patients with IBD and to determine the risk factors for severe COVID-19.
Methods. The analysis included 68 patients with an established diagnosis of Crohns disease (CD) or ulcerative colitis and a confirmed new coronavirus infection. The diagnosis of coronavirus infection was established when SARS-CoV-2 was detected by PCR using nasopharyngeal smears, and computer tomography (CT) of the chest revealed inflammatory changes characteristic of coronavirus lung damage or high IgG and IgM titers based on the results of immunological blood analysis.
Results. 68 patients with IBD and COVID-19 were observed in the Department of IBD, including 27 (39.7%) patients with CD, 41 (60.3%) patients with UC. Among patients diagnosed with pneumonia, 100 % of patients received therapy with thiopurines and infliximab. 8 (11.8%) patients were diagnosed with COVID-19 during hospitalization for a severe IBD attack. There was no statistically significant difference between UC and CD patients in terms of disease activity (p = 0.13) during the period of coronavirus infection. In 37 patients (26 UC, 11 BC) with pneumonia (100%), there was an exacerbation of IBD. Statistical significance was found between the development of more severe lung damage (CT 34) and IBD activity at the time of diagnosis of COVID-19 (p 0.001), the presence of comorbidities (p 0.001) and taking GCS (p 0.001) at the time of detection of COVID-19. However, the use of biological and immunosuppressive therapy was not associated with a higher risk of severe lung damage and the need for a ventilator. It was shown that the age of patients over 65 years was statistically correlated with the need for a ventilator (p = 0.02).
Conclusion. The exacerbation of the disease, especially in elderly patients with comorbidities, the use of glucocorticosteroids was associated with negative consequences of COVID-19, while biological and immunosuppressant drugs used for the treatment of IBD did not have such a negative effect.Обоснование. COVID-19 это инфекционный респираторный синдром с широким спектром проявлений и исходов. Пациенты с воспалительными заболеваниями кишечника (ВЗК) имеют больший риск инфицирования SARS-CoV-2, в особенности если они получают иммуносупрессивную терапию.
Цель исследования описать проявления COVID-19 у пациентов с ВЗК и определить факторы риска тяжелого течения COVID-19.
Методы. В анализ были включены 68 пациентов c установленным диагнозом болезни Крона (БК) или язвенного колита (ЯК) и подтвержденной новой коронавирусной инфекцией. Диагноз коронавирусной инфекции устанавливался при выявлении SARS-CoV-2 методом ПЦР назофарингеальных мазков, выявлении при компьютерной томографии (КТ) органов грудной клетки воспалительных изменений, характерных для коронавирусного поражения легких, или высокого титра IgG и IgM по результатам иммунологического анализа крови.
Результаты. 68 пациентов с ВЗК и COVID-19 наблюдались в отделении лечения Московского клинического научно-практического центра имени А.С. Логинова, из них 27 (39,7%) пациентов с БК, 41 (60,3%) пациент с ЯК. Не было выявлено статистически значимого различия между пациентами ЯК и БК в отношении активности заболевания (p = 0,13) в период коронавирусной инфекции. У 37 пациентов (26 с ЯК, 11 с БК) с пневмонией (100%) имелось обострение ВЗК. У 8 (11,8%) пациентов был диагностирован COVID-19 во время госпитализации по поводу тяжелой атаки ВЗК. Была выявлена статистическая значимость между развитием более тяжелого поражения легких (КТ 34) и активностью ВЗК на момент диагностирования COVID-19 (p 0,001), наличием сопутствующих заболеваний (p 0,001) и приемом ГКС (p 0,001) на момент выявления COVID-19. При этом применение биологической и иммуносупрессивной терапии не было связано с более высоким риском тяжелого поражения легких и потребностью в ИВЛ. Было показано, что возраст пациентов более 65 лет статистически коррелировал с потребностью в ИВЛ (p = 0,02).
Заключение. Обострение заболевания, в особенности у пожилых пациентов с сопутствующей патологией, и прием глюкокортикостероидов имели зависимость с негативными последствиями COVID-19, в то время как препараты биологической и иммуносупрессорной терапии, применяемые для лечения ВЗК, не оказывали такого негативного влияния
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at TeV
The inclusive transverse momentum () distributions of primary
charged particles are measured in the pseudo-rapidity range as a
function of event centrality in Pb-Pb collisions at
TeV with ALICE at the LHC. The data are presented in the range
GeV/ for nine centrality intervals from 70-80% to 0-5%.
The Pb-Pb spectra are presented in terms of the nuclear modification factor
using a pp reference spectrum measured at the same collision
energy. We observe that the suppression of high- particles strongly
depends on event centrality. In central collisions (0-5%) the yield is most
suppressed with at -7 GeV/. Above
GeV/, there is a significant rise in the nuclear modification
factor, which reaches for GeV/. In
peripheral collisions (70-80%), the suppression is weaker with almost independently of . The measured nuclear
modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/284
Measurement of charm production at central rapidity in proton-proton collisions at TeV
The -differential production cross sections of the prompt (B
feed-down subtracted) charmed mesons D, D, and D in the rapidity
range , and for transverse momentum GeV/, were
measured in proton-proton collisions at TeV with the ALICE
detector at the Large Hadron Collider. The analysis exploited the hadronic
decays DK, DK, DD, and their charge conjugates, and was performed on a
nb event sample collected in 2011 with a
minimum-bias trigger. The total charm production cross section at TeV and at 7 TeV was evaluated by extrapolating to the full phase space
the -differential production cross sections at TeV
and our previous measurements at TeV. The results were compared
to existing measurements and to perturbative-QCD calculations. The fraction of
cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/307
Particle-yield modification in jet-like azimuthal di-hadron correlations in Pb-Pb collisions at = 2.76 TeV
The yield of charged particles associated with high- trigger
particles ( GeV/) is measured with the ALICE detector in
Pb-Pb collisions at = 2.76 TeV relative to proton-proton
collisions at the same energy. The conditional per-trigger yields are extracted
from the narrow jet-like correlation peaks in azimuthal di-hadron correlations.
In the 5% most central collisions, we observe that the yield of associated
charged particles with transverse momenta GeV/ on the
away-side drops to about 60% of that observed in pp collisions, while on the
near-side a moderate enhancement of 20-30% is found.Comment: 15 pages, 2 captioned figures, 1 table, authors from page 10,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/350
Effect of event selection on jetlike correlation measurement in d+Au collisions at sNN=200 GeV
AbstractDihadron correlations are analyzed in sNN=200 GeV d+Au collisions classified by forward charged particle multiplicity and zero-degree neutral energy in the Au-beam direction. It is found that the jetlike correlated yield increases with the event multiplicity. After taking into account this dependence, the non-jet contribution on the away side is minimal, leaving little room for a back-to-back ridge in these collisions
Beam-energy Dependence Of Charge Balance Functions From Au + Au Collisions At Energies Available At The Bnl Relativistic Heavy Ion Collider
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Balance functions have been measured in terms of relative pseudorapidity (Δη) for charged particle pairs at the BNL Relativistic Heavy Ion Collider from Au + Au collisions at sNN=7.7GeV to 200 GeV using the STAR detector. These results are compared with balance functions measured at the CERN Large Hadron Collider from Pb + Pb collisions at sNN=2.76TeV by the ALICE Collaboration. The width of the balance function decreases as the collisions become more central and as the beam energy is increased. In contrast, the widths of the balance functions calculated using shuffled events show little dependence on centrality or beam energy and are larger than the observed widths. Balance function widths calculated using events generated by UrQMD are wider than the measured widths in central collisions and show little centrality dependence. The measured widths of the balance functions in central collisions are consistent with the delayed hadronization of a deconfined quark gluon plasma (QGP). The narrowing of the balance function in central collisions at sNN=7.7 GeV implies that a QGP is still being created at this relatively low energy. © 2016 American Physical Society.942CNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoMinistry of Education and Science of the Russian FederationMOE, Ministry of Education of the People's Republic of ChinaMOST, Ministry of Science and Technology of the People's Republic of ChinaNRF-2012004024, National Research FoundationNSF, National Stroke FoundationConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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